Year: 2026 | Month: April | Volume: 16 | Issue: 4 | Pages: 225-230
DOI: https://doi.org/10.52403/ijhsr.20260427
A Functional Nutrition Approach to Leptin Resistance and Thyroid Dysfunction in a 52-Year-Old Female: A Case Report
Snigdha Ranjan1, Aakansha Tamhane2, Saloni Kulkarni3, Mugdha Pradhan4
1M.Sc., Researcher, Thrivetribe Wellness Solutions Private Limited
2,3M. Sc., Functional Nutritionist, Thrivetribe Wellness Solutions Private Limited, Pune, India
4M.Sc., Expert Functional Nutritionist, Thrivetribe Wellness Solutions Private Limited, Pune, India
Corresponding Author: Snigdha Ranjan
ABSTRACT
Background: Leptin resistance, insulin resistance, chronic inflammation, and thyroid dysfunction commonly coexist in metabolic disorders, contributing to weight persistence, fatigue, and impaired energy regulation. Addressing these interconnected issues requires personalized nutritional strategies.
Case Presentation: A 52-year-old female with a history of metabolic dysfunction and systemic inflammation presented with elevated leptin and insulin levels, thyroid imbalance, and micronutrient deficiencies. Blood parameters were closely monitored, and a root cause analysis guided a tailored functional nutrition intervention. A low-carbohydrate, leptin-focused dietary plan emphasizing protein, fiber, and anti-inflammatory foods was implemented alongside targeted supplementation. Lifestyle adjustments included meal timing, gentle post-meal movement, and stress management practices.
Discussion: Over three months, the patient demonstrated significant clinical and biochemical improvements, including reduced serum leptin (91 to 64.6 ng/mL), improved insulin sensitivity (fasting insulin 18.2 to 8.9 µIU/mL), normalized thyroid function (TSH 5.21 to 4.04 µIU/mL), and meaningful weight loss (87 to 81 kg). Energy levels and digestive comfort also improved, highlighting the efficacy of integrated nutritional therapy in complex metabolic dysfunction.
Conclusion: This case underscores the potential of personalized functional nutrition to effectively address leptin resistance, insulin resistance, and thyroid dysfunction, improving metabolic health and quality of life.
Key words: Leptin resistance, thyroid dysfunction, inflammation, fatigue, functional nutrition