Year: 2025 | Month: September | Volume: 15 | Issue: 9 | Pages: 324-330
DOI: https://doi.org/10.52403/ijhsr.20250933
Role of Metabolic and Inflammatory Biomarkers in Acute Stroke Patients Admitted in a Tertiary Care Hospital: Clinical Correlation of Lipid Profile, LDH, CPK, CRP, and HbA1c
Sandeep Kumar Shukla1, Dr. Rajeev Kumar Dubey2, Sanjay Bharati3
1Ph.D. Scholar, Department of Anaesthesiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India- 221005
2Professor, Department of Anaesthesiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India - 221005
3Ph.D. Scholar, Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India- 221005
Corresponding Author: Sandeep Kumar Shukla
ABSTRACT
Introduction: Stroke remains a significant public health concern in India, with increasing incidence and suboptimal outcomes. Biochemical markers may aid in distinguishing stroke subtypes and assessing disease severity, especially in resource-constrained settings.
Methods: A hospital-based observational study was conducted on 52 patients with acute stroke admitted to a tertiary care centre in Northern India. Patients were classified into ischaemic and haemorrhagic stroke based on neuroimaging. Blood samples were analysed for total cholesterol, LDL, HDL, triglycerides, VLDL, C-reactive protein (CRP), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), and glycated haemoglobin (HbA1c). Group-wise comparisons were conducted using statistical tests selected based on data characteristics and test assumptions.
Result: Ischaemic stroke was more prevalent (88.5%) than haemorrhagic stroke. HbA1c (6.6% vs. 4.8%, p<0.01), CRP (30.6 vs. 20.1 mg/L, p=0.01), and CPK (198.4 vs. 142.3 IU/L, p=0.02) were significantly elevated in ischaemic stroke. LDH was higher in haemorrhagic stroke (p=0.03), while HDL was significantly lower in ischaemic stroke (p=0.04).
Conclusion: Biochemical markers such as CRP, HbA1c, and CPK show significant differences between stroke subtypes. Their routine assessment may improve early differentiation and guide management strategies in acute stroke, particularly in settings with limited imaging access.
Key words: Acute stroke, CRP, HbA1c, LDH, CPK, lipid profile, ischaemic stroke, haemorrhagic stroke.