Year: 2025 | Month: November | Volume: 15 | Issue: 11 | Pages: 157-164
DOI: https://doi.org/10.52403/ijhsr.20251120
Assessment of Cognition in Prediabetics in a Tertiary Care Hospital of Tamil Nadu - A Cross-Sectional Study
Leela Priyadharsini Balamurali1, Dharani M2, Neelamegam U3
1Assistant Professor, Department of Physiology, Dhanalakshmi Srinivasan Institute of Medical Sciences and Hospital, Perambalur, Tamil Nadu, India
2Department of Physiology, Government Medical College, Tiruvallur, Tamil Nadu, India
3Assistant Professor, Department of Physiology, Dhanalakshmi Srinivasan Institute of Medical Sciences and Hospital, Perambalur, Tamil Nadu, India
Corresponding Author: Leela Priyadharsini Balamurali
ABSTRACT
Introduction: Prediabetes is more common in young adults. The worldwide prevalence of Impaired Glucose tolerance (IGT) was found to be 343 million (7.8%). In India the prevalence of Pre-diabetes is found to be 10.6%. Cognition refers to all the mental activities involved in receiving information, comprehending it, sorting, retrieving, and using it. Cognitive decline is one of the neurological complications of prediabetes.
Aim: To evaluate whether cognition is impaired in the pre-diabetic patients when compared to that of clinically healthy individuals
Materials and methods:
This is a descriptive cross-sectional study conducted in a tertiary care hospital in Tamil Nadu. The participants for this study were selected from the Non-Communicable Disease (NCD) Clinic of the hospital and from the community. The recording of event related cognitive evoked potential response for all the participants was recorded in the research lab - human experiments laboratory in the department of Physiology.
Results: The N1 latency (msec), P2 latency (msec), N2 latency (msec) and P300 latency (msec) in prediabetics were 132.6+34.4, 179.7+36.6, 246.6+39.9 and 346.2+27.6. The N1 latency (msec), P2 latency (msec), N2 latency (msec) and P300 latency (msec) in controls were 111.5+10.2, 153.6+9.5, 205+15.1 and 317+11.3. The N2-P300 amplitude (mvolt) in prediabetics and control were 3.6+1.6 and 6.1+4.2 respectively. The difference is statistically significant. (p<0.05)
Conclusion: There exists a prolonged latency and decrease in amplitude in pre-diabetic patients which was proved significant, compared to normal individuals.
Key words: Prediabetes, Cognition, Cognitive evoked potential, Impaired glucose tolerance, Impaired fasting glucose.