IJHSR

International Journal of Health Sciences and Research

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Year: 2025 | Month: October | Volume: 15 | Issue: 10 | Pages: 191-194

DOI: https://doi.org/10.52403/ijhsr.20251021

Complete Androgen Insensitivity Syndrome Diagnosed in Infancy: A Case Report

Soumya Rajan Mohanty1, Mallavarapu Manisha2

1DM Endocrinology & Metabolism, Senior Resident, Department of Endocrinology & Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi
2DM Endocrinology & Metabolism, Senior Resident, Department of Endocrinology & Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi

Corresponding Author: Soumya Rajan Mohanty

ABSTRACT

Complete androgen insensitivity syndrome (CAIS) is a rare X-linked disorder characterized by a 46 XY karyotype and phenotypically female external genitalia due to complete end-organ resistance to androgens. Most cases are diagnosed in adolescence during evaluation of primary amenorrhea. Diagnosis in infancy is less common and usually occurs when inguinal masses or hernias are evaluated. We report the case of a 6-month-old infant with CAIS who presented with female-like external genitalia and inguinal swelling, highlighting the diagnostic approach, differential diagnoses, and clinical management considerations.

Key words: Androgen insensitivity syndrome, 46 XY DSD, inguinal hernia, karyotype

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