Year: 2025 | Month: October | Volume: 15 | Issue: 10 | Pages: 89-95
DOI: https://doi.org/10.52403/ijhsr.20251010
Natural but Not Harmless? Essential Oils, Endocrine Activity, and Gynecomastia in Boys
Samaera Rana1, Dr. Adarsh Keshari2, Dr. Rhea Aggarwal3, Kainat Hussain4
1Independent Researcher, Prometheus School, Noida, India
2Senior Research Fellow, APAR Health, Gurugram, India
3Co-Founder, APAR Health, Gurugram, India
4Junior Research Fellow, APAR Health, Gurugram, India
Corresponding Author: Dr. Adarsh Keshari
ABSTRACT
Essential oils, extracted from a wide range of plants, are increasingly incorporated into cosmetics, personal care products, and aromatherapy preparations, and are often promoted as safe and natural choices for children and families. Among these, lavender (Lavandula angustifolia) and tea tree (Melaleuca alternifolia) oils are the most widely used. However, despite their popularity and perceived safety, growing evidence suggests that these oils may have endocrine-disrupting effects.
Case reports have linked chronic topical exposure to prepubertal gynecomastia in boys, with complete regression of symptoms upon discontinuation, suggesting a modifiable environmental risk factor. Mechanistic studies reinforce this association by demonstrating that key constituents, including linalool, linalyl acetate, and terpinen-4-ol, activate estrogen receptors and inhibit androgen receptors, providing biological plausibility. While epidemiological studies have not consistently shown population-level effects, their methodological limitations preclude firm conclusions and do not exclude rare but clinically meaningful outcomes in susceptible subgroups. Regulatory oversight remains limited, as cosmetic products containing essential oils are not subject to comprehensive premarket toxicological testing, and labelling practices rarely disclose individual constituents.
Collectively, these findings challenge the assumption that “natural equals safe.” The convergence of clinical evidence, mechanistic plausibility, and regulatory gaps highlights the need for expanded research to define safe exposure thresholds, identify vulnerable populations, and clarify long-term risks. Until such evidence is available, a precautionary approach is warranted, particularly in products marketed for children.
Key words: Essential oils, Lavender oil (Lavandula angustifolia), Tea tree oil (Melaleuca alternifolia), Endocrine disruption, Prepubertal gynecomastia, Estrogen receptor activation, Androgen receptor inhibition, Linalool, Linalyl acetate, Terpinen-4-ol, Cosmetic regulation