Year: 2024 | Month: April | Volume: 14 | Issue: 4 | Pages: 173-176
DOI: https://doi.org/10.52403/ijhsr.20240425
Carbamazepine Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Case Report
Shaik Khadeer Ahamad1, Deepthi Dara2, Sanjana Reddy Thota2, Nehika Mukundu2, Rama Rao Tadikonda3
1Assistant Professor, Department of Pharm D, CMR College of Pharmacy, Hyderabad, Telangana, India.
2Pharm D students, CMR College of Pharmacy, Hyderabad, Telangana, India.
3Principal, Department of Pharmaceutical chemistry, CMR College of Pharmacy, Hyderabad, Telangana, India.
Corresponding Author: Shaik Khadeer Ahamad
ABSTRACT
Stevens-Johnson syndrome and toxic epidermal necrolysis are acute life-threatening mucocutaneous drug reactions. Early symptoms of this syndrome include fever and blisters that peel and leave painful raw areas. As the infection progresses, consequences like dehydration, sepsis, pneumonia, and multiple organ failure are common. In this report the authors present case of a 28-years-old male patient referred to our hospital after taking carbamazepine for seizures and developing high-grade fever and skin lesion initially on upper trunk maculopapular followed by all over body including eyes and oral cavity. The use of IVIG and plasmapheresis was a good management for our case, helping in our patient's well-being and recovery.
Key words: Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), mucocutaneous, plasmapheresis, carbamazepine