Year: 2023 | Month: December | Volume: 13 | Issue: 12 | Pages: 145-151
DOI: https://doi.org/10.52403/ijhsr.20231218
Clinicohematological Perspective and Dual Case Reports of Bone Marrow Metastasis with Review of Literature
Dr. Vaidehi Nagar1, Dr. Nanda Patil2
1Resident of Pathology, Krishna Vishwa Vidyapeeth Deemed to be University, Karad
2Professor of Pathology, Krishna Vishwa Vidyapeeth Deemed to be University, Karad
Corresponding Author: Dr. Vaidehi Nagar
ABSTRACT
Metastatic tumours frequently include bone marrow as a primary site of metastasis. The presence of bone marrow metastases has been observed in several tumour types, with the most prevalent occurrences found in prostate, breast and lung carcinomas among adults and in small round cell tumours within the paediatric group. The presence of solid tumour metastases in the bone marrow is indicative of an advanced disease stage and is associated with a poor prognosis. In this study, we report two instances of malignancies that have demonstrated metastasis to the bone marrow. Specifically, we focus on gastric adenocarcinoma and mantle cell lymphoma, examining their respective patterns of bone marrow involvement and associated haematological findings. The bone marrow examination is a simple, effective, sensitive and cost-effective method for determining the stage and monitoring the prognosis of solid tumours.
Key words: bone marrow, metastasis, prognosis, metastatic gastric adenocarcinoma, spillover of mantle cell lymphoma