Original Research Article
Year: 2019 | Month: February | Volume: 9 | Issue: 2 | Pages: 46-50
Normal T4, T3, TSH Levels in Adult Sudanese in Khartoum State, Sudan
Abdelmuhsin H. Mohamed1, Amir A. Bashir2, Asim A. Osman1, Elnagi Y. Hajo3, Kamal M. Awad1, Najlaa M.Abass4, Ibrahim A. Ali5, Elmutaz H. Taha6, Amal M. Saeed7, Omer A. Musa5
1Department of Physiology, Faculty of Medicine, Gadarif University, Sudan.
2Department of Physiology, Faculty of Medicine, Al-EmamAlmahady University, Sudan.
3Department of Physiology, Faculty of Medicine, Aldeain University, Sudan.
4Department of Physiology, Faculty of medicine, Bahri University, Sudan.
5Department of Physiology, Faculty of Medicine, National Ribat University, Sudan.
6Department of Physiology, Faculty of medicine, Dongla University, Sudan.
7Department of Physiology, Faculty of Medicine, Khartoum University, Sudan.
Corresponding Author: Abdelmuhsin H. Mohamed
Introduction: Thyroid dysfunctions (hypo- and hyperthyroidism) are common clinical disorders in Sudan. The diagnosis of these conditions depends on measurement of TSH, T4, and T3. Sudanese hospitals and clinics normal reference values are obtained from non-Sudanese subjects. The aim of this study to establish the normal T4, T3, and TSH levels in adult Sudanese. The normal range of T4, T3, and TSH for Americans in United States (T4= 4.5 -11.5 ug/dl, T3= 0.8 - 2.0 ng/ml, TSH= 0.5 – 5.0 IU/L)
Methods: A cross sectional study was done in Khartoum state from September 2016 to November 2018. 311 healthy adult Sudanese aged 20 to 60 years (males= 59 females= 252) were selected from staff, students and employers of two randomly selected governmental universities (Khartoum & Bahri). Personal data and clinical history were taken by a questionnaire. 5ml of Blood sample was obtained from anti-cubital vein from each subject between 8:00 AM to 11:00 AM. The separated blood sera were immediately stored at - 20 °C for later measurements of TSH, T4, and T3. The samples were analyzed for TSH, T4 and T3 by AIA-360 Fluorometric Enzymatic Immunoassay by using TOSOH manufactures.
Results: The Mean ±SD for TSH was 1.7 ± 1.1 uIU/ ml, for T3 was 1.2 ± 0.3 ng/ml and for T4 was found to be 7.5± 1.5 ug/dl with a range TSH= 0.6 to 2.8 uIU/ ml, T3= 0.7 to 1.5 ng/ml and T4 = 6 to 9 ug/dl. The mean value of T4 was slightly higher in males (males= 7.7±1.5, females= 7.5 ±1.6 ug/dl) while TSH was higher in females (females= 1.8 ± 1.1, males= 1.6 ± 0.9 uIU/ ml)
Conclusion: The range value of T4, T3, and TSH were found to be lower when it is compared with international reference values. The mean of T3 in underweight participants was found to be significantly lower than acceptable BMI (P= 0.003).
Key words: Normal values, Thyroid hormones, Thyrotropin