Original Research Article
Year: 2018 | Month: August | Volume: 8 | Issue: 8 | Pages: 136-140
Monitoring of Adverse Drug Reactions of Anti-Epileptic Agents in the Neurology Department
Nitin Handa, Ranbir Singh
Research Scholar, Department of Pharmacy Practice, ISF College of Pharmacy, Moga-Ferozepur G.T. Road Moga, 142001, Punjab, India.
Corresponding Author: Ranbir Singh
Purpose: To monitor the adverse drug reaction of anti-epileptic agents. Other objectives were to study the pattern of ADRs caused by the antiepileptic drugs used in neurology department and the side effects by spontaneous reporting.
Methods: A prospective observational study was conducted in the neurology department and The patients who fulfilled the inclusion criteria were recruited in the study. The data were analyzed by SPSS Statistics ver. 20.
Results: During the study period, 54 patients developed Adverse drug reaction from anti-epileptic agents in the neurology department. Most reactions occurred in the age group 31-40 years (37%) followed by 41-50 year age group (25%) developed ADRs. More common reaction or problem is skin rashes; occurred in 12 patients (20.4%). Tab Depran (clonazepam + Escitalopram) caused the highest number of adverse drug reaction in 11 patients (20.4%). All the ADRs were caused by the drug taken through the oral route. As per Naranjo probability scale, causality assessment was probable in 40 patients (74.1%).the majority of drugs were withdrawn after the occurrence of adverse drug reaction (35 patients). No serious reaction occurred at the time of the study.
Conclusion: Most of the ADRs were inevitable due to the poor predictability of the ADRs and poorly understood mechanisms to explain their causes, Pharmacovigilance program should be implemented and awareness should be created among physician about reporting any suspected adverse drug reaction so that unreported ADRs and unknown risk factor could be identified and data generated will help Indian regulatory authorities to make appropriate regulatory decision which will benefit the society & people.
Key words: First line ART failure, risk factors, protective factors, independent factors.