Original Research Article
Year: 2018 | Month: May | Volume: 8 | Issue: 5 | Pages: 111-116
Carcinoma Lower Lip: An Experience from a Regional Cancer Centre of North-East India
Dr. Nizara Baishya1, Dr. Tashnin Rahman1, Dr. Ashok Kumar Das1, Chandi Ram Kalita2,
Dr. Rajjyoti Das1, Dr. Anindita Bhagawati3
1Department of Head and Neck Surgery, Dr. B Borooah Cancer Institute, Guwahati, India,
2Department of Dental Surgery, Regional Dental College, Guwahati, India,
3Hospital Based Cancer Registry, Dr. B Borooah Cancer Institute, Guwahati, India,
Corresponding Author: Dr. Nizara Baishya
ABSTRACT
Objective: Carcinoma of lip is a common malignant neoplasm of the oral cavity, with the lower lip more commonly involved than the upper lip. The purpose of the present study is to assess the clinicopathological features as a prognostic indicator for carcinoma lower lip.
Materials and method: 79 patients of lower lip carcinoma treated at Dr. B. Borooah Cancer Institute, a Regional Cancer Centre from 2010 to 2015 were considered. Survival analysis were estimated by Kaplan-Meier curves and log-rank test was done to examine the differences. P<0.05 were regarded as statistically significant.
Results: 75.9% patients were males and 24.1% were females. Median age was 60.0 years. All the surgically operated cases were included in the study with squamous cell carcinoma (SCC) in 87.3% and12.7% of verrucous carcinoma. 24/79 (30.4%) patients had recurrence either at the primary site, regional or distant during the follow up period. The tumor factors like positivity of lymph node (pN) and muscle involvement by the tumor were statistically significant for disease recurrence. A 5 year DFS for early and late pathological tumor stage (pT) were 62.8% and 45% respectively (p=.205) and tumor size (60%vs 52.4%).Overall survival at 5-year follow-up for early and late composite stage were 79.4% and 54.7% respectively.
Conclusion: Muscle invasion and lymph node positivity are the criterion for recurrence of disease. Some biomarkers need to be investigated to assess the therapeutic effect and improve the overall prognosis of the disease.
Key words: Carcinoma, lower lip, recurrence, survival