Original Research Article
Year: 2017 | Month: March | Volume: 7 | Issue: 3 | Pages: 36-41
LDLr Gene Expressions: A Novel Biomarker in Risk Prediction of Renal Injury
Khot VV, Yadav KS
School of Medicine, D Y Patil University, Navi Mumbai 400706 India
Corresponding Author: Yadav KS
ABSTRACT
Background: Patients with uncontrolled diabetes prone to ESRD, require kidney transplantation, haemodialysis or peritoneal dialysis which adds psychological distress. Early detection of kidney injury by evaluating gene expressions of LDLr in T2DM with microalbuminuria minimizes the risk of DN. Present research work conducted at the Department of Biochemistry, D.Y.Patil school of Medicine, Navi Mumbai, India.
Methods: This is cross-sectional analytical study includes 241 subjects (118 male, 123 women, and age ranges 30-70 years). Categorization of subjects in three study groups were done on the basis of T2DM duration 3-5 years, Glycosylated haemoglobin level (HbA1c) ≥ 7.0 % with fasting blood glucose ≥126 mg/dl) and microalbuminuria (30-300 mg/dl), equal number of healthy volunteers enrolled in control group. Blood samples were processed for other renal parameters by photometry assay & LDLr expressions by RT-PCR.
Results: All renal and lipids parameters are within normal range except albumin/creatinine ratio (p>.012), e-GFR (p>.00) and cholesterol (p>.00). Descriptive analysis showed high significance (p>.00) for LDLr in microalbuminuria subjects.
Conclusion: Screening biochemical renal parameters are not enough to prevent DN. Early detection of LDLr gene expressions predicts risk of kidney injury. Early intervention may prevent damage to kidney due to diabetic nephropathy.
Key words: Diabetes mellitus, microalbuminuria, LDLr gene expression, risk prediction.