Original Research Article
Year: 2017 | Month: March | Volume: 7 | Issue: 3 | Pages: 150-159
The Role of Stem Cell Markers in the Diagnosis of Periodontitis
Abrar A Bannani1*, AbdulAzizSGul2**, Mohammad N Redwan1*, Wed A. Baghdadi1*, Amal M. Eldeeb3*
1Post Graduate Student, 2Demonstrator, 3Professor,
*Oral Pathology Department, **Oral Surgery Department,
Faculty of Dentistry, Umm Al-Qura University, Saudi Arabia.
Corresponding Author: Abrar A Bannani
ABSTRACT
Aim: This study was conducted to compare the levels of salivary CD44 in periodontally diseased smokers and non-smokers, and compare them with healthy subjects.
Materials and methods: A total of 40 patients, were divided according the presence or absence of the disease into two groups: Group I (Control group): 10 patients. Group II (Periodontally diseased): 30 patients, divided into two subgroups: Group II A (Smokers): 15 and Group II B (Non-Smokers): 15.
Patients who presented with chronic periodontitis identified via the plaque index, gingival index (GI), probing depth and clinical attachment level using Williams periodontal probe, along with the intraoral periapical radiographs.
The saliva samples were collected from each patient using Navazesh's Unstimulated method and testing the CD44 levels using ELISA. SPSS software was used for all statistical analyses.
Results: The higher mean of CD44 13.5 was recorded in (Group I) followed by (Group II B) 10.3, and the lower mean was recorded in (Group II A) 6.0 .The difference in mean CD44 between the groups was found to be statistically non significant (P > 0.01).
Conclusion: Based on the finding of the present study it could be concluded that the mean level of CD44 was higher in healthy group more than that in non-smokers chronic periodontitis group, and the lower mean was recorded in smokers-chronic periodontitis group. It may be suggested that smoking increase periodontal destruction and decrease the regeneration capacity of the tissue and this may lead to decrease the level of salivary CD44.
Key words: Stem cell marker, Periodontitis.