Original Research Article
Year: 2017 | Month: February | Volume: 7 | Issue: 2 | Pages: 141-145
Role of HbA1c and Microalbumin as an Early Risk Marker of Diabetic Nephropathy
Prithvi Bahadur Shah1, Arun Acharya1, Sabina Shrestha2, Sujan Shrestha2
1Department of Biochemistry, Norvic International Hospital, Kathmandu, Nepal
2Department of Pathology, Norvic International Hospital, Kathmandu, Nepal
Corresponding Author: Prithvi Bahadur Shah
ABSTRACT
Aim: The aim of this study was to correlate glycosylated hemoglobin and urinary microalbumin and to compare urinary microalbumin level between different groups as an early risk marker of Diabetic nephropathy.
Methods: The study was conducted among six hundred individuals attending Out-patient department at Norvic International Hospital, Kathmandu, Nepal. Glycosylated hemoglobin was estimated using NycoCard Boronate affinity assay and urinary microalbumin level was estimated using NycoCard solid phase, sandwich-format Immunometric assay.
Results: Statistically significant differences were observed in mean value of glycosylated hemoglobin and urinary microalbumin in different groups i.e. Normal control, Poor control, and Bad Control. Mean value were (5.96 ± 0.38) (8.45 ± 5.24) (p=0.024); (7.5 ± 0.75) (25.81 ± 33.24) (p=0.002); (10.5 ± 1.24) (35.01 ± 46.36) (p= 0.000), respectively. After applying ANOVA in different groups of urinary microalbumin, mean differences were noted and were statistically significant (p<0.05).
Conclusion: This study suggests aggravating glycemic control triggers excretion of high urinary microalbumin.
Key words: Glycosylated hemoglobin, urinary microalbumin, Diabetic Nephropathy, Glycemic control