Case Report
Year: 2017 | Month: January | Volume: 7 | Issue: 1 | Pages: 291-296
Langerhans Cell Histiocytosis of the Oral Mucosa: A Rare Case Report
Mounir Omami1, Abdellatif Chokri2, Sameh Sioud3, Mariem Meddeb1, Adel Bouguezzi2, Hajer Hentati3, Jamil Selmi4
1Resident, 2Associate Professor, 3Professor, 4Professor and Head of Department,
Department of Medicine and Oral Surgery, University Dental Clinic of Monastir, Tunisia.
Corresponding Author: Mounir Omami
ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare idiopathic disease characterized by the clonal proliferation of bone marrow derived Langerhans cells. It usually occurs in children. Their clinical features simulate common oral findings such as gingival enlargement, oral ulcers, and mobility of teeth, along with nonspecific radiographic features, thus easily leading to the misdiagnosis and therefore, it could be overlooked by dentists. We report a rare case of LCH in 38‑year‑old adult male, characterized by oral mucosal ulcerations with no involvement of the underlying bone. The lesion was histologically proven to be LCH and was confirmed with immunohistochemical staining of S100 protein and CD1a antigen.
Key words: Langerhans cell histiocytosis-ral cavity-oral ulcer-immunohistochemistry.