Year: 2024 | Month: March | Volume: 14 | Issue: 3 | Pages: 81-86
DOI: https://doi.org/10.52403/ijhsr.20240314
Markers of Oxidative Stress Evaluation in People Living with Pulmonary Tuberculosis
Dr Anil Batta
Professor & Head, Dept. of Biochemistry, Muzaffarnagar Medical College, Muzaffarnagar
ABSTRACT
Pulmonary tuberculosis (TB) is one of the most common infectious diseases globally. This study was done to assess the levels of vitamins C and E, glutathione peroxidase, catalase, superoxide dismutase, and lipid peroxidation product (malondialdehyde) in pulmonary tuberculosis patients in Muzaffarnagar Medical College & Hospital, Muzaffarnagar (MMC). A total of 90 individuals (males and females), comprising 30 newly diagnosed pulmonary tuberculosis patients yet to commence therapy. Thirty old cases on therapy and a control group consisting of 30 healthy individuals of the same age range (35-55 years). The levels of Vitamin C, Vitamin E, glutathione peroxidase, catalase, and superoxide dismutase in pulmonary tuberculosis were determined using the standard method. The results showed that the levels of Vitamin C (1.64±0.41 mg/dl), Vitamin E (1.46±0.38 mg/dl), glutathione peroxidize (0.89±0.07 iu/L), catalase (70.49±2.02 iu/L) and superoxide dismutase (65.45±3.48 iu/L) in pulmonary tuberculosis were significantly decreased when compared with controls ( 1.91±0.42 mg/dl, 0.84±0.31 mg/ldl, 72.60±2.58 iu/L, 0.94±0.06 iu/L, 68.65±2.83 iu/L) respectively (p<0.05). While the level of malondialdehyde (8.7±1.81 mol/ml) was significantly increased (p<0.05) in pulmonary tuberculosis when compared with control (4.91±1.90 mol/ml). However, the levels of antioxidants were increased in pulmonary tuberculosis on antituberculosis drugs when compared with those not on therapy. These probably indicate that antioxidant status is significantly reduced in pulmonary tuberculosis patients which may be associated with high levels of free radicals and oxidative stress. Hence, supplementation of pulmonary tuberculosis patients with diet or drugs containing antioxidants can improve their condition.
Key words: Pulmonary tuberculosis, antioxidant, oxidative stress