Year: 2024 | Month: January | Volume: 14 | Issue: 1 | Pages: 291-297
DOI: https://doi.org/10.52403/ijhsr.20240137
Comparison of Ondansetron V/S Dexamethasone for Preventing Post-Operative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy - An Observational Study
Revathy AM1, Dr. Vasantha OT2, Rudra Mol R3
1Assistant Professor, Department of Anaesthesia and OT Technology, Yenepoya School of Allied Health Sciences-Yenepoya (deemed to be a university) Mangalore, India
2Professor, Department of Anaesthesiology, Yenepoya Medical College(Yenepoya deemed to be a university), Mangalore, India
3Assistant Professor, Department of Anaesthesia and OT Technology, Yenepoya School of Allied Health Sciences-Yenepoya (deemed to be a university) Mangalore, India
Corresponding Author: Dr. Vasantha OT
ABSTRACT
BACKGROUND AND OBJECTIVES: Postoperative nausea and vomiting (PONV) are one of the foremost common complications of anaesthesia. To enhance patient outcomes and satisfaction, it is crucial to identify efficient approaches to prevent or eliminate post-operative nausea and vomiting. The most widely used medications for post-operative nausea and vomiting prophylaxis in current day practice are ondansetron and dexamethasone. The current study aims to compare the efficacy of 4mg ondansetron and 8mg dexamethasone in preventing postoperative nausea and vomiting following laparoscopic cholecystectomy.
MATERIALS AND METHOD: The observational study includes 78 patients who underwent laparoscopic cholecystectomy. Patients was randomly allocated into group A or group B. patients in group A received injection ondansetron and patients in group B received injection dexamethasone. The episodes of Post operative nausea and vomiting were observed using a 4-point ordinal scale at intervals of 0-3 hours and 3-24 hours after surgery. For statistical association, The Mann- Whitney U test is used to compare the proportion of nausea and vomiting in two drug groups; a p-value less than 0.05 is considered significant.
RESULTS: The episodes of PONV in 0-3 hours (p= 0.928) were comparatively higher than in 3-24 hours (p=0.360) following surgery. The episodes of PONV were found to be less with dexamethasone than ondansetron in the late 3-24 hours although it was not statistically significant.
CONCLUSION: The intraoperative use of either Dexamethasone 8mg or ondansetron 4 mg for patients undergoing laparoscopic cholecystectomy appears to reduce the incidence of PONV but does not reach statistical significance.
Key words: Ondansetron, Dexamethasone, post-operative nausea vomiting, laparoscopic cholecystectomy