Original Research Article
Year: 2023 | Month: September | Volume: 13 | Issue: 9 | Pages: 1-6
DOI: https://doi.org/10.52403/ijhsr.20230901
Study of Glycaemic Control in Thyroid Patients
Karanpal Singh1, Dr. Sushil Yadav2, Dr. Sangeeta Kapoor3, Dr. Harekrishna Sharma4
1M.Sc. Medical Biochemistry3rd year, Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad-244001, (U.P), India
2Assistant Professor, Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad-244001, (U.P), India
3Professor & H.O.D, Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad-244001, (U.P), India
4Associate Professor, Department of Medicine, Teerthanker Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad-244001, (U.P), India
Corresponding Author: Dr. Sushil Yadav
ABSTRACT
Introduction: Thyroid gland produces and secretes thyroid hormones, tri-iodothyronine (T3) and thyroxine (T4). Increased levels of thyroid hormones among hyperthyroid cases lead to hyperglycaemia by promoting absorption of glucose through gastrointestinal tract and also increasing glycogenolysis. On the other hand, reduced thyroid hormone levels in hypothyroidism lead to decreased gastrointestinal glucose uptake, delayed peripheral glucose assimilation, and reduced gluconeogenesis. Due to this altered state of metabolism seen in thyroid complications, serum FPG & HbA1c levels are significantly affected.
Objectives: To estimate levels of fasting plasma glucose (FPG) and HbA1c among patients of thyroid dysfunction and compare F.P.G & HbA1c with thyroid parameters, meanwhile to correlate glycaemic parameters with thyroid parameters.
Methods: Diagnosed cases of Thyroid disorder Patients under the consultation of medicine department attending medicine OPD of TMMC&RC with Age group 18- 65 years were taken as the study group following up on inclusion & exclusion criteria.
Results: There was a significant difference in mean values of HbA1c in euthyroid & hypothyroid cases. Also, a significant difference in mean HbA1c values was seen in comparison of euthyroid and hyperthyroid cases. Also, a significant difference in mean values of FPG in euthyroid & hypothyroid cases was observed.
Conclusion: Patients with thyroid disorders are vulnerable to impaired glycaemic control, specifically hypothyroid patients. Regular monitoring of FPG and HbA1c is required along with assessment of thyroid parameters of T3 T4 & TSH levels.
Key words: glycaemic control, hypothyroid, hyperthyroid, F.P.G, HbA1c