Year: 2023 | Month: December | Volume: 13 | Issue: 12 | Pages: 1-11
DOI: https://doi.org/10.52403/ijhsr.20231201
Influence of Parental History of Hypertension on Frequency Domain Parameters of Heart Rate Variability (HRV) and Serum Lipid Profile in Prehypertensives
Vanathy Karunamoorthy1, Gayathri. R2, Priyadarsini. D3, Meena. A4
1,2,3,4Department of Physiology,
1,2,3Assistant professor, 4Associate professor, Bhaarath Medical College and Hospital,
Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
Corresponding Author: Vanathy Karunamoorthy
ABSTRACT
Background: Parental history and dyslipidemia are the most important non modifiable risk factor and modifiable risk factor for developing hypertension respectively. Many research studies have documented the role of the autonomic nervous system in the control of blood pressure. And heart rate variability is a non-invasive tool to assess the sympathovagal balance. Prehypertensives are at an increased risk of developing hypertension and other cardiovascular diseases. Hence our study aims at evaluating the role of parental history of hypertension on the sympathovagal balance and serum lipid profile parameters in prehypertensive individuals.
Aims & Objectives:
The aim of the study was
To assess the sympathovagal balance by recording the frequency domain parameters of heart rate variability in prehypertensives with and without parental history of hypertension.
To estimate the serum lipid profile parameters in prehypertensives with and without parental history of hypertension.
To correlate sympathovagal balance (LF:HF ratio) and serum lipid profile parameters in them.
Methods:
Study Area: Institute of Physiology and Experimental Medicine, Madras Medical College, Chennai, Tamilnadu, India.
Study Population: Prehypertensive individuals with systolic blood pressure between 120 – 139mmHg or Diastolic blood pressure between 80 – 89mmHg.
Sample size: 60 prehypertensive individuals (30 with parental history and 30 without parental history of hypertension) selected from non-communicable diseases clinic, Rajiv Gandhi Government General Hospital, Tamilnadu, Chennai.
Results: There was no significant difference in age, body mass index between the prehypertensives with and without parental history. There was increased sympathetic drive in prehypertensives with parental history and the sympathovagal balance was altered and was suggestive of sympathetic overactivity in them. The serum lipid profile parameters like total cholesterol, Triglycerides, Low density lipoprotein was significantly elevated in prehypertensives with parental history. Also the increase in lipid profile parameters (total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein) correlated with increase in the sympathovagal imbalance. A decrease in high density lipoprotein correlated with the increase in sympathovagal imbalance in prehyperetensives with parental history.
Key words: Heart rate variability, Lipid profile, Prehypertension, Symapthovagal Balance.