Year: 2023 | Month: October | Volume: 13 | Issue: 10 | Pages: 234-242
DOI: https://doi.org/10.52403/ijhsr.20231032
Pattern of Lipid Profile and Fasting Blood Glucose Among Human Immunodeficiency Virus Positive Patients on First Line Drugs Over 24 Months Period in Metabolic Syndrome Study in Sokoto Nigeria
Bello Aminu1, Anaja O. Peter2, Rasheed Yusuf3, Muhammad B. Abdul Rahman4, Abubakar A. Fakku5, Umar A. Abdullahi7, Saidu Kasimu7
1,4,5,6,7Department of Chemical Pathology and Immunology, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
2,3Department of Chemical Pathology, Faculty of Basic Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Kaduna State. Nigeria
Corresponding Author: Bello Aminu
ABSTRACT
Background: The introductions of highly active antiretroviral therapy (HAART) has improved the live expectancy of patients with HIV/AIDS, but is associated with increase cardiovascular related morbidity among the recipient of the drugs.
Objectives: The aim of this study was to determine the prevalence of dyslipaedemias and the factors associated with lipid profile derangement among HIV positive patients on first line drugs.
Materials and Methods: This prospective study was conducted between July 2019 and June 2021. Eighty-six (86) HIV seropositive HAART naïve subject were recruited for the study at institute of human virology centres (IHVN) of Usmanu Danfodiyo University Teaching Hospital Sokoto. Lipid profile and fasting blood glucose were estimated after overnight fast and National cholesterol Education program adult treatment panel was used to determine dyslipaedemias and cut off for fasting blood glucose level. Baseline sample were taking before commencing the participants on first line ART regiment and flow up for twenty-four months (24 months). Repeated sample collection was done at six months intervals. The data were collected using interviewer administer questionnaire and analyses using SPSS IBM Statistical package version 23v.
Results: Of the eighty-six-participant recruited for the study, 47(54.7%) were female and 39(45.3%) are male. The baseline data was collected before placing the patients on first line antiretroviral drugs containing Lamivudine Tenofovir and Dolutegravil combination for all the patient. The mean age was 34.98 years, mean body mass index 19.22kg/M2 and mean WHR was 0.84. Mean SBP and DBP was 110.6mmHg and 75.3mmHg respectively. The prevalence of hyperglycaemia, hypercholesterolemia, hypertriglyceridemia’s, LDL-C hypercholesterolaemia and decrease HDL-C at baseline were 5.9%, 0%, 52.3%, 1.2%, and 55.9% respectively. Nonetheless the prevalence of dyslipidaemias and hyperglycaemia was statistically increase after commencing ART over the period of 24 months.
Conclusion: In this study of newly diagnosed HIV positive patients’ lipids were irregularly elevated at baseline through 24 months, HDL-C is the most derange lipid component seen among HIV positive patients HAART naïve and HAART exposed patients.
Key words: Pattern, Lipid profile, Blood glucose, metabolic syndrome, Study.