Original Research Article
Year: 2022 | Month: March | Volume: 12 | Issue: 3 | Pages: 160-168
DOI: https://doi.org/10.52403/ijhsr.20220322
Comparative Evaluation of Antidepressant Property of Unmad Gajkesari Rasa and Fluoxetine Hydrochloride w.s.r. to Chronic Unpredictable Mild Stress Induced Depression (Avasad) in Wistar Rats
Gaurav S. Bansod1, Vinod Ramteke2, Raman Belge3, A. P. Somkuwar4, Alka Sawarkar5
1P.G. Scholar, Dept. of Rasashastra & Bhaishjya Kalpana, Shri Ayurved Mahavidyalaya, Nagpur
2Associate Professor & P.G. Guide, Dept. of Rasashastra & Bhaishjya Kalpana, Shri Ayurved Mahavidyalaya, Nagpur
3Professor & H.O.D, Dept. of Rasashastra & Bhaishjya Kalpana, Shri Ayurved Mahavidyalaya, Nagpur
4Professor and Head, Department of Veterinary Pharmacology and Toxicology, Nagpur Veterinary College, Nagpur
5Assistant Professor, Department of Veterinary Pharmacology and Toxicology, Nagpur Veterinary College, Nagpur
Corresponding Author: Vd. Gaurav S. Bansod
ABSTRACT
Depression (Avasad) is a medical disorder of the brain that affects feeling, thoughts, behaviour and physical health of person. Worldwide 450 million individuals are suffering from mental illness. Various researches have been done on development of disease, its pathophysiology, epidemiology and other aspects, but very few research works are available on its therapeutic aspect from ayurvedic view. There is a need to find a therapeutic solution for Depression (Avasad) and this study is aimed at the same.Unmad Gajkesari Rasa (UGR) a herbomineral formulation mentioned in Yogratnakar Unmad rog 27/1-3 is indicated for treatment of Manas Vyadhi.
AIM: To compare antidepressant property of Unmad Gajkesari Rasa & Fluoxetine Hydrochloride w.s.r. to chronic unpredictable mild stress induced Depression (Avasad) in wistar rats.
Materials and Methods:UGR was prepared as per reference of Yogratnakar. Wistar Rats were subjected to CUMS (Chronic Unpredictable Mild Stress) for induction of depression followed by oral administration of UGR & Fluoxetine Hydrochloride orally.
Observation:Histopathological parameters & anti-depressant property of UGR & Fluoxetine Hydrochloride in wistar rats.
Conclusion: The result of the Unmad Gajkesari Rasa a herbomineral formulation suggested that it had a significant antidepressant activity as compared to Fluoxetine hydrochloride in tail suspension test and weight.
Key words: Anti-depressant activity, Depression (Avasad), Fluoxetine hydrochloride, Unmad Gajkesari Rasa, Wistar rats.