Original Research Article
Year: 2021 | Month: September | Volume: 11 | Issue: 9 | Pages: 187-191
DOI: https://doi.org/10.52403/ijhsr.20210929
Evaluation of Serum Gamma-Glutamyl Transferase Activity and Serum Uric Acid Level in Type II Diabetes Mellitus Patients
KM Devi1, R. K Patil2, Mandeep Malhi3, H. C Patil4
1Student, B. Pharmacy, Adesh Institute of Pharmacy and Biomedical Sciences, Bathinda
2Professor, Department of Pharmacy Practice, Adesh Institute of Pharmacy and Biomedical Sciences,
Bathinda
3Lecturer, Department of Pharmaceutics, Adesh Institute of Pharmacy and Biomedical Sciences,
Bathinda
4Professor & Principal, Department of Pharmacy Practice, Adesh Institute of Pharmacy and Biomedical Sciences, Bathinda
Corresponding Author: RK Patil
ABSTRACT
Studies in past few years have linked oxidative stress as a potential marker of diabetes mellitus. Thus, based on the previous literature this study was planned with the aim to evaluate serum GGT activity and serum uric acid level as potential indicators of oxidative stress in type-2 diabetes mellitus patients.
A total of 68 participants were included following inclusion and exclusion criteria. After the statistical analysis, statistically significant differences were observed in the mean GGT activity between controls (30.19±7.639IU/L) and cases (59.386±22.215IU/L) (p=0.000). Similarly, mean serum uric acid level of controls (5.180±1.476mg/dl) and cases (3.510±0.792mg/dl) (p=0.000), were also statistically difference.
Further, after applying Pearson’s correlation, positive correlation between GGT and HbA1C level (r=0.390) and with GGT and FPG level (r=0.375) were observed. However, correlation between HbA1c and uric acid (r=-0.372); FPG and uric acid (r=-0.374) level suggested serum uric acid concentration was inversely proportional to the degree of dysglycemia in diabetes mellitus patients of this study.
Hence, results of this study suggested serum GGT activity and serum uric acid level were altered as compared to controls and cases. Thus, further study on these parameters may help to serve it as potential markers of oxidative stress in diabetes mellitus patients.
Key words: Diabetes mellitus, HbA1C, GGT, Uric acid and Oxidative stress.