Review Article
Year: 2021 | Month: February | Volume: 11 | Issue: 2 | Pages: 200-206
Role of Glycosaminoglycans and Matrix Metalloproteinases in Aggressive Behavior of Myxomas: a Review with Report of Two Cases of Odontogenic Myxoma of Anterior Jaws
Verma Ashish1, Joshi Jaya2, Bishen Kundendu A.3, Fazeela Aashi M.4
1PG student, 2Professor and Head, 3Lecturer, Department of Oral Pathology and Microbiology Govt. College Dentistry, Indore (M.P)
4Department of Oral Pathology and Microbiology Govt. College Dentistry, Indore (M.P)
Corresponding Author: Ashish Verma
ABSTRACT
Myxomas are soft tissue benign neoplasms commonly associated with Carney’s Complex as cardio-cutaneous myxomas. Odontogenic myxoma is a rare variant occurring in head neck region and is considered to be originated from ectomesenchymal portion of developing tooth germ. It is a slow growing non metastasizing tumour exclusively seen in jaw bones but may also be present in other soft tissues of oral cavity. It shows a locally invasive biological behavior which results may results in marked facial asymmetry. Histochemical analysis of myxomas has abundance of Glycosaminoglycans which are thought to be responsible for their aggressive behavior. The glycosaminoglycans present in Odontogenic Myxoma can be identified and quantified using Immunohistochemical and histochemical methods respectively. Here we report two cases of Odontogenic Myxomas showing dissimilar clinical presentations with respect to gender, age, size and site and a review on the histochemical composition of myxomatous tissue and its possible role in its biological behavior.
Key words: Odontogenic Myxoma, infiltrative nature, histochemical analysis, Glycosaminoglycans, Matrix metalloproteinases.