Original Research Article
Year: 2020 | Month: June | Volume: 10 | Issue: 6 | Pages: 334-337
Fetuin-A and hs-CRP Levels in Subclinical Hypothyroidism
G.G. Kaushik1, Manjubala Maheriya2, Ankita Sharma3, Charu Gunjal4
1Sr.Professor, Department of Biochemistry, J.L.N. Medical College, Ajmer.
2M.Sc. student, Department of Biochemistry, J.L.N. Medical College, Ajmer.
3Sr. Demonstrator, Department of Biochemistry, J.L.N. Medical College, Ajmer.
4M.Sc. student, Department of Biochemistry, J.L.N. Medical College, Ajmer.
Corresponding Author: Manjubala Maheriya
ABSTRACT
Subclinical Hypothyroidism is a clinical condition in which levels of TSH increased with normal FT4 levels. It is asymptomatic in general may progress to overt hypothyroidism. Fetuin-A is liver derived glycoprotein which act as inhibitor of ectopic mineralization and can be contributing factor in insulin resistance or in metabolic syndrome. High-sensitivity C-reactive protein (hs-CRP) in inflammation is more sensitive non-specific marker of infection and tissue damage which help to quantify low grade of systemic inflammation in the absence of overt systemic inflammation disorder. The aim of study was to determine the levels of Fetuin-A and hs-CRP in SCH patients and compare it with healthy Euthyroid control. In this observational study 65 newly diagnosed Subclinical Hypothyroid Subjects and 130 age and gender matched euthyroid subjects acting as control were included. Serum concentrations of TSH, FT3, FT4, Fetuin-A and hs-CRP levels were assessed. The study showed that the mean serum Fetuin-A level in SCH subjects (293.4±76.5 µg/ml) is found statistically significantly lower than Euthyroid control (347.24±134.52µg/ml; P < 0.0001). The mean hs-CRP level of SCH subjects (5.43 ±4.19mg/L) is found higher than Euthyroid controls (1.61 ± 1.3 mg/L; p<0.0001). Hence, it is concluded that in addition to levels of TSH, Fetuin-A together with hs-CRP can also be used as diagnostic measure and may be helpful in initiating treatment for SCH subjects.
Key words: Fetuin-A, hs-CRP, SCH, TSH