Original Research Article
Year: 2020 | Month: January | Volume: 10 | Issue: 1 | Pages: 18-23
Hematological Inflammatory Parameters: Can They Play a Role as Cancer Biomarkers?
Anu Agarwal1, Hiral2, Mukta Pujani3, Sujata Raychaudhuri4, Charu Agarwal4, Akanksha Bajaj1, Reetika Menia1
1Tutor, 2MBBS Student, 3Associate Professor, 4Assistant Professor,
Department of Pathology, ESIC Medical College and Hospital, Faridabad, Haryana
Corresponding Author: Anu Agarwal
ABSTRACT
Background: Cancer is one of the most important causes of morbidity and mortality worldwide. Association of cancer with systemic inflammation has been widely established. A complete blood count may reveal changes in cell lines as a result of inflammation.
Method: The study was conducted in the Department of Pathology at ESIC Medical College, Faridabad in duration of 3 months (July 2018- September 2018). A total of 30 cancer cases and 30 controls were included in the study. The haematological parameters (neutrophil, lymphocyte, monocyte count and platelet count) and indices (NLR, PLR and LMR) were evaluated and statistical analysis was done to find a relationship between the above mentioned indices and cancer.
Result: According to our study NLR and PLR along with absolute neutrophil count and platelet count showed a significant difference between cancer cases and controls. However, there was no significant difference between cancer and control groups in terms of LMR values.
Conclusion: Absolute neutrophil and platelet count alongwith NLR and PLR can be used as markers of systemic inflammation in cancer
Key words: cancer, systemic inflammation, haematological indices