Original Research Article
Year: 2020 | Month: January | Volume: 10 | Issue: 1 | Pages: 135-145
Diagnostic Performance of the TG/HDL-C Ratio in the Prediction of Insulin Resistance in Brazzaville, Republic of Congo
Reine Freudlendrich Eboka-Loumingou Sakou1, Benjamin Longo-Mbenza2,5,6, Guenole Guie1, Albert Mûnka Nkalla-Lambi3, Etienne Mokondjimobe4, José Simo Louokdom1, Henry Germain Monabeka4, Herve Alex Tukadila5, Alexis Dockekias Elira1, Ange Antoine Abena1, Aliocha Nkodila Natuhoyila5, Donatien Moukassa4
1National Laboratory of Public Health, Brazzaville, Republic of Congo, Faculty of Health Sciences, Marien Ngouabi University. Brazzaville, Republic of Congo,
2Department of Internal Medicine, University of Kinshasa, Democratic Republic of Congo,
3Leyono Municipal Clinic, Brazzaville, Republic of Congo
4Faculty of Health Sciences, Marien Ngouabi University. Brazzaville, Republic of Congo, Hospital and University Center. Brazzaville, Republic of Congo
5Lomo University of research, Kinshasa, Democratic republic of Congo,
6Faculty of Health Sciences, Walter Sisulu University. Mthatha, South Africa,
Corresponding Author: Benjamin Longo-Mbenza
ABSTRACT
Insulin resistance (IR) is an excellent predictor of type 2 diabetes mellitus, its measure is a key approach to prevent the development of cardiometabolic diseases. Recent studies suggest that the triglyceride-to-high-density lipoprotein ratio is a biomarker for predicting insulin resistance. The objective of this study was to assess the diagnostic performance of the TG/HDL-C ratio compared to the HOMA-IR score in insulin resistance in Brazzaville, Republic of Congo. A cross-sectional study was conducted with 500 participants at least 18 years of age apparently healthy in a population of Brussels, Republic of Congo. Insulin resistance was defined by the evaluation of the insulin resistance homeostasy model (HOMA-IR - 2.5). Univariate/ROC and multivariate/logistical regression analyses were used respectively to obtain diagnostic performance of insulin resistance. The prevalence of insulin resistance was 28% (n-140). There was a positive and significant correlation (p-0,0001) between HOMA-IR and the TG/HDL-C ratio. The optimal threshold value of the TG/HDL-C ratio was 2.5 with a sensitivity of 0.85 [95% IC- 0.81-0.89] and a specificity of 0.73 [95% CI-0.65-0.80]. The area under the curve (ASC) was 0.79 [95% CI- 0.74-0.83] (Model 1). After multiple logistic regression and adjustment for sex, age, waist circumference, hip circumference alone the TG/HDL-C ratio - 2.5 and BMI - 30 Kg/m2 were the independent determinants of insulin resistance (HOMA-IR - 2.5). The TG/HDL-C ratio of 2.5 can be considered a simple and accurate subtitute biomarker in the diagnosis of insulin resistance in Congolese adults.
Key words: prediction, insulin resistance, HOMA-IR, TG/HDL-C, Brazzaville.