Original Research Article
Year: 2020 | Month: December | Volume: 10 | Issue: 12 | Pages: 17-24
Histopathological Spectrum of Interface Dermatitis and Its Clinicopathological Correlation
Reeta Dhar1, Priyanka Gaikwad2, Jyotsna Sahai3, Shilpi Sahu4
1,4Professor; 2,3Resident, MGM Medical College, Navi Mumbai, Maharashtra
Corresponding Author: Priyanka Gaikwad
ABSTRACT
Introduction: ‘Interface dermatitis’ term is used when at low power there is a Lichenoid tissue reaction seen showing band of dense inflammatory infiltrates obscuring the dermo-epidermal junction. The histopathological features of all the lesions of Interface dermatitis overlap each other showing very minute difference in each of the variants and the interpretation of these lesions require both histopathological and clinical correlation. The aim of the present study was - 1) To analyse the histomorphological changes in various lesions of Lichenoid tissue reactions. 2) To correlate the clinical features with the histopathological diagnosis in all the cases suspected to have lichenoid tissue reaction and to analyse the age and sex distribution
Material and methods: Present study was a retrospective evaluation of 104 cases diagnosed to have Lichenoid tissue reaction in the department of pathology of a tertiary care hospital for a period of 5 years, from January 2015 to December 2019. Patients diagnosed clinically as Lichenoid tissue reaction were included in this study. Biopsy was taken in the department of dermatology of the same hospital. All biopsies were fixed in formalin and then processed in histopathology section, stained with hematoxylin and eosin stain and various epidermal and dermal features noted.
Result: Out of total 104 cases, clinicopathological correlation revealed concordance in 82 cases (78.84%) and discordance was seen in 22 cases (21.21%). Female preponderance was observed with male to female ratio as 1:1.4. Maximum numbers of cases were between the age group of 21 years to 50 years of which most of the cases were diagnosed as Lichen planus.
Conclusion: Present study was done to understand the clinical and histopathological features of various lesions of Interface Dermatitis. As it is difficult to distinguish various lesions of Interface Dermatitis clinically, a detailed histopathological examination is needed for early diagnosis and appropriate, timely treatment.
Key words: Lichen planus, Interface dermatitis, Histopathology.